MidwestSports.Net ranks the top 10 football teams in the midwest region in NCAA Division II and NAIA for Oct. 21, 2018.
DIVISION II
| Ranking | Team | Record | Previous | Last Week / This Week |
| 1 | Ouachita | (8-0) | 1 | Def. Southern Nazarene, 41-0 Oct. 27 at Arkansas-Monticello |
| 2 | Northwest Missouri | (7-1) | 2 | Def. Lindenwod, 38-17 Oct. 27 at Northeastern State |
| 3 | Southern Arkansas | (7-1) | 3 | Def. East Central, 48-9 Oct. 27 vs. Henderson State |
| 4 | Fort Hays State | (6-2) | 4 | Def. Neb.-Kearney, 29-26 2OT Oct. 27 vs. Lindenwood |
| 5 | Pittsburg State | (6-2) | 5 | Def. Central Missouri, 48-28 Oct. 27 at Missouri Western |
| 6 | Harding | (6-2) | 6 | Def. Northwestern Okla., 38-7 Oct. 20 at East Central |
| 7 | Missouri S&T | (6-2) | 8 | Def. Quincy, 20-13 Oct. 27 vs. Lincoln |
| 8 | Central Oklahoma | (5-3) | 9 | Def. Washburn, 34-0 Oct. 27 at Missouri Western |
| 9 | Chadron State | (5-3) | NR | Def Dixie State, 30-18 Oct. 20 vs. N. M. Highlands |
| 10 | Southeastern Oklahoma | (5-3) | 7 | Lost to Henderson State, 20-17 Oct. 27 vs. Arkansas Tech |
NAIA
| Ranking | Team | Record | Previous | Last Week / This Week |
| 1 | Morningside | (8-0) | 1 | Def. Northwestern, 42-34 Oct. 27 vs. Concordia |
| 2 | Kansas Wesleyan | (8-0) | 4 | Def. McPherson, 76-38 Oct. 27 at Bethel |
| 3 | Langston | (6-1) | 5 | Def. Lyon, 48-21 Oct. 27 at Texas College |
| 4 | Benedictine | (7-1) | 6 | Def. Culver-Stockton, 49-13 Oct. 27 vs. William Penn |
| 5 | Northwestern (Iowa) | (6-1) | 2 | Lost to Morningside, 42-34 Oct. 27 at Hastings |
| 6 | Evangel | (8-1) | 3 | Lost to MidAmerica Nazarene, 33-26 Oct. 27 at Culver-Stockton |
| 7 | Avila | (6-1) | 7 | Def. Ottawa, 25-21 Oct. 27 at Bethany |
| 8 | Grand View | (6-1) | 9 | Def. Graceland, 56-14 Oct. 27 at Culver-Stockton |
| 9 | Southwestern (Kan.) | (6-2) | 10 | Def. Bethel, 45-14 Oct. 27 at Ottawa |
| 10 | Ottawa | (6-2) | 8 | Lost to Avila, 25-21 Oct. 27 vs. Southwestern |